Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease.

@article{Gehrman2009MelatoninFT,
  title={Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease.},
  author={Philip R Gehrman and Donald J. Connor and Jennifer L. Martin and Tamar Shochat and Jody Corey-Bloom and Sonia Ancoli-Israel},
  journal={The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry},
  year={2009},
  volume={17 2},
  pages={166-9}
}
OBJECTIVES Patients with Alzheimer dementia often display both agitated behavior and poor sleep. Given that the disease is often associated with low endogenous levels of melatonin, exogenous melatonin administration may lead to improvements in sleep and agitation. DESIGN Randomized, placebo-controlled study. SETTING Nursing homes in San Diego, CA, metropolitan area. PARTICIPANTS Subjects were patients with probable Alzheimer disease. INTERVENTION Melatonin (8.5 mg immediate release and… CONTINUE READING
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