Melatonin enhances the rewarding properties of morphine: involvement of the nitric oxidergic pathway.

Abstract

Melatonin has different interactions with opioids including the enhancement of the analgesic effects of morphine and also reversal of tolerance and dependence to morphine. The present study assessed the effect of melatonin on morphine reward in mice using a conditioned place preference (CPP) paradigm. Our data showed that subcutaneous administration of… (More)

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