Melatonin enhances antinociceptive effects of delta-, but not mu-opioid agonist in mice.

Abstract

This present study examines the effect of melatonin on antinociceptive action induced by opioid agonists in mice using the tail-flick test. When injected either by intraperitoneal (i.p.) (1, 5, 25 mg/kg) or by intracerebroventricular (i.c.v.) (0.25, 0.5, 1 mg/kg) routes, melatonin significantly enhanced the delta-opioid agonist deltorphin I induced… (More)

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@article{Li2005MelatoninEA, title={Melatonin enhances antinociceptive effects of delta-, but not mu-opioid agonist in mice.}, author={Shi-Rong Li and Ting Wang and Rui Wang and Xu Dai and Qiang Chen and Ren-de Li}, journal={Brain research}, year={2005}, volume={1043 1-2}, pages={132-8} }