Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist.

  title={Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist.},
  author={Deborah L. Drazen and Donna Bilu and Staci D. Bilbo and Randy J. Nelson},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={280 5},
  • D. L. DrazenD. Bilu R. Nelson
  • Published 1 May 2001
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
In addition to marked seasonal changes in reproductive, metabolic, and other physiological functions, many vertebrate species undergo seasonal changes in immune function. Despite growing evidence that photoperiod mediates seasonal changes in immune function, little is known regarding the neuroendocrine mechanisms underlying these changes. Increased immunity in short days is hypothesized to be due to the increase in the duration of nightly melatonin secretion, and recent studies indicate that… 

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