Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment

@article{JeanLouis1998MelatoninEO,
  title={Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment},
  author={Girardin Jean-Louis and Hans von Gizycki and Ferdinand Zizi},
  journal={Journal of Pineal Research},
  year={1998},
  volume={25}
}
Key MethodThe effects of immediate-release melatonin on circadian rest-activity profiles, cognition, and mood were investigated in ten elderly individuals with self-reported sleep-wake disturbances. Melatonin (6 mg), administered 2 hr before habitual bedtime, enhanced the rest-activity rhythm and improved sleep quality as observed in a reduction in sleep onset latency and in the number of transitions from sleep to wakefulness. However, total sleep time was not significantly increased nor was wake within…
Cognitive effects of exogenous melatonin administration in elderly persons: a pilot study.
TLDR
Melatonin administration at a dose of 1 mg nightly may be effective in improving certain aspects of cognitive functioning and subjective reports of sleep quality in elderly subjects.
Circadian misalignment and sleep disruption in mild cognitive impairment.
TLDR
Circadian misalignment and sleep disruption is evident in patients with MCI, and is consistent with changes observed in Alzheimer's disease, and could be a marker for disease trajectory and may even be implicated in disease pathogenesis.
Melatonin Efficacy to Treat Circadian Alterations of Sleep in Alzheimer’s Disease
TLDR
Melatonin prevented the chronobiological consequences of injecting β amyloid peptide 25–35 in the SCN of hamsters and cognitive decay in transgenic mice overexpressing β-amyloid, and could be beneficial in AD by augmenting the restorative phase of sleep.
Effect of melatonin-rich night-time milk on sleep and activity in elderly institutionalized subjects
TLDR
Even ultra-low doses of melatonin may benefit the elderly by increasing their daytime activity, as studied in elderly institutionalized subjects in two long-term double-blind, placebo-controlled, crossover studies.
Melatonin and Quality of Life
TLDR
Melatonin has a promising role in cancer patients not only as an oncostatic drug but also in promoting their general physical health and well-being and Meditation, besides improving QOL, coincidentally enhances the secretion of melatonin from the pineal gland, thus suggesting that melatonin may be an important physical mediator of the meditation experience.
Therapeutic application of melatonin in mild cognitive impairment.
TLDR
Melatonin can be a useful add-on drug for treating MCI in a clinic environment and improved cognitive and emotional performance and daily sleep/wake cycle in MCI patients exhibited significantly better performance in Mini-Mental State Examination and the cognitive subscale of the Alzheimer's disease Assessment Scale.
Sleep–wake profiles predict longitudinal changes in manic symptoms and memory in young people with mood disorders
TLDR
It is suggested that some sleep–wake and circadian disturbances in young people with mood disorders may be associated with less favourable longitudinal outcomes, notably for subsequent manic symptoms and memory difficulties.
Optimizing Circadian Rhythm and Characterizing Brain Function in Disorders of Consciousness
TLDR
It is shown that it is possible to improve sleep and circadian rhythms of patients with PDOC, and most importantly, this improvement leads to increase in Coma Recovery Scale-Revised scores.
...
...

References

SHOWING 1-10 OF 60 REFERENCES
Melatonin replacement therapy of elderly insomniacs.
TLDR
It is suggested that for melatonin-deficient elderly insomniacs, melatonin replacement therapy may be beneficial in the initiation and maintenance of sleep.
Changes in the Sleep and Waking EEGs of Nondemented and Demented Elderly Subjects
TLDR
Monitoring of sleep and waking EEGs from healthy nondemented elderly men and inpatients for whom the diagnosis was probable senile dementia of Alzheimer's type suggested that correlative neuropathologic data might provide an understanding of the basis for the sleep, EEG, and mental‐function factors that undergo change in SDAT.
Neuroendocrine rhythms and sleep in aging men.
TLDR
It is demonstrated that the normal process of aging involves alterations in the central mechanisms controlling the temporal organization of endocrine release in addition to a reduction of secretory outputs.
Alzheimer's disease. Sleep and sleep/wake patterns.
Melatonin and adjustment to phase shift
TLDR
Melatonin has clear circadian phase‐shifting effects in humans which have recently been formalized as a phase response curve and its potential use in circadian rhythm disorders has been investigated in field studies of jet lag and shift work and in simulated phase shift.
...
...