Melatonin down-regulates MDM2 gene expression and enhances p53 acetylation in MCF-7 cells.

@article{Proietti2014MelatoninDM,
  title={Melatonin down-regulates MDM2 gene expression and enhances p53 acetylation in MCF-7 cells.},
  author={Sara Proietti and Alessandra Cucina and Gabriella Dobrowolny and Fabrizio D'Anselmi and Simona Dinicola and Maria Grazia Masiello and Alessia Pasqualato and Alessandro Palombo and Ver{\^o}nica de C{\'a}ssia Morini and Russell J Reiter and Mariano Bizzarri},
  journal={Journal of pineal research},
  year={2014},
  volume={57 1},
  pages={120-9}
}
Compelling evidence demonstrated that melatonin increases p53 activity in cancer cells. p53 undergoes acetylation to be stabilized and activated for driving cells destined for apoptosis/growth inhibition. Over-expression of p300 induces p53 acetylation, leading to cell growth arrest by increasing p21 expression. In turn, p53 activation is mainly regulated in the nucleus by MDM2. MDM2 also acts as E3 ubiquitin ligase, promoting the proteasome-dependent p53 degradation. MDM2 entry into the… CONTINUE READING
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