• Biology, Chemistry, Medicine
  • Published in The Biochemical journal 1991
  • DOI:10.1042/bj2800727

Melatonin biosynthesis and metabolism in peripheral blood mononuclear leucocytes.

@article{Finocchiaro1991MelatoninBA,
  title={Melatonin biosynthesis and metabolism in peripheral blood mononuclear leucocytes.},
  author={Liliana Mar{\'i}a Elena Finocchiaro and Victor Elias Nahmod and Jean Marie Launay},
  journal={The Biochemical journal},
  year={1991},
  volume={280 ( Pt 3)},
  pages={
          727-31
        }
}
Cultured human peripheral blood mononuclear leucocytes (PBML) were able to synthesize indoleamines, including melatonin, and were also able to convert melatonin taken up from the incubation medium into N-acetyl-5-hydroxytryptamine (NAHT) and 5-hydroxytryptamine (5-HT). These compounds were analysed by h.p.l.c., and melatonin was additionally characterized by two-dimensional t.l.c., mass spectrometry and radioimmunoassay. Only hydroxyindoles were detected by h.p.l.c. in unstimulated PBML culture… CONTINUE READING

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