Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling.

@article{Shin2015MelatoninAN,
  title={Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling.},
  author={In-sik Shin and Na-Rae Shin and Ji-Won Park and Chan-Mi Jeon and Ju-Mi Hong and Ok-Kyoung Kwon and Joong-sun Kim and In-Chul Lee and Jong-choon Kim and Sei-Ryang Oh and K S Ahn},
  journal={Journal of pineal research},
  year={2015},
  volume={58 1},
  pages={50-60}
}
The incidence of chronic obstructive pulmonary disease (COPD) has substantially increased in recent decade. Cigarette smoke (CS) is the most important risk factor in the development of COPD. In this study, we investigated the effects of melatonin on the development of COPD using a CS and lipopolysaccharide (LPS)-induced COPD model and cigarette smoke condensate (CSC)-stimulated NCI-H292 cells, a human mucoepidermoid carcinoma cell. On day 4, the mice were treated intranasally with LPS. The mice… CONTINUE READING

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