Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

@article{Abraham2010MelatoninAM,
  title={Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats},
  author={Premila Abraham and Viswa Kalyan Kolli and Suganthy J. Rabi},
  journal={Cell Biochemistry and Function},
  year={2010},
  volume={28}
}
Nephrotoxicity is an adverse side effect of methotrexate (MTX) chemotherapy. The present study verifies whether melatonin, an endogenous antioxidant prevents MTX‐induced renal damage. Adult rats were administered 7 mg/kg body weight MTX intraperitoneally for 3 days. In the melatonin pretreated rats, 40 mg/ kg body weight melatonin was administered daily intraperitoneally 1 h before the administration of MTX. The rats were killed 12 h after the final dose of MTX/vehicle. The kidneys were used… Expand
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TLDR
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Administration of crocin improves the damage caused by MTX in rats, by the establishment of balance in the levels of antioxidant prevents the damage to the renal cell membrane, and subsequently the renal damage repairs. Expand
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TLDR
A role for mitochondrial dysfunction and oxidative stress in the mechanism of MTX nephrotoxicity is suggested. Expand
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TLDR
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Melatonin ameliorates the drug induced nephrotoxicity: Molecular insights.
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The comprehensive nephroprotection and safer profile suggests the melatonin to be a useful adjunct to improve the safety of nephrotoxic drugs. Expand
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References

SHOWING 1-10 OF 58 REFERENCES
Melatonin prevents methotrexate‐induced hepatorenal oxidative injury in rats
TLDR
The present study suggests that melatonin may be of therapeutic benefit when used with MTX and elucidates the role of free radicals in MTX‐induced toxicity and the protection by melatonin. Expand
Neutrophil Infiltration and Oxidative Stress May Play a Critical Role in Methotrexate-Induced Renal Damage
TLDR
Evidence is provided for the role of neutrophil infiltration and oxidative stress in MTX-induced renal damage and administration of inhibitors of myeloperoxidase or scavenging hypochlorous acid by supplementation with antioxidants as an adjuvant therapy may be promising in alleviating the renal side effect of MTX. Expand
Methotrexate-induced renal oxidative stress in rats: the role of a novel antioxidant caffeic acid phenethyl ester
TLDR
Investigation of the role of caffeic acid phenethyl ester (Caffeic Ester), a novel antioxidant, on methotrexate-induced renal oxidative stress in rats found that it leads to a reduction in antioxidant enzymatic defense capacity and causes lipid peroxidation in renal tissue. Expand
Methotrexate Causes Oxidative Stress in Rat Kidney Tissues
TLDR
It has been suggested that MTX leads to oxidative stress in rat kidney tissues, which might be one of the reasons for MTX-induced nephrotoxicity. Expand
Melatonin improves methanol intoxication‐induced oxidative liver injury in rats
TLDR
In conclusion, melatonin has protective effects against methanol‐induced hepatic injury and in melatonin treated group piecemeal necrosis, lobular lytic necrosis and portal inflammation returned to normal histologic appearances when compared with meetinghanol administration. Expand
Melatonin reduces mortality and oxidatively mediated hepatic and renal damage due to diquat treatment
TLDR
Melatonin, a broad spectrum antioxidant, reduces hepatic and renal damage and lowers the death rate in diquat‐treated mice. Expand
Reduction of carbon tetrachloride‐induced nephropathy by melatonin administration
TLDR
Melatonin provided protection against CCl4‐induced renal toxicity as was evident by histopathological evaluation and it is suggested that melatonin protects kidneys against C Cl4 toxicity. Expand
[Effect of melatonin on hyperoxia-induced oxidant/antioxidant imbalance in the lung of neonatal rats with chronic lung disease].
TLDR
Melatonin may reverse oxidant/antioxidant imbalance in hyperoxia-induced lung disease, thus providing a protective effect against CLD in neonatal rats. Expand
Antioxidative effects of melatonin administration in elderly primary essential hypertension patients
TLDR
Results indicate an improvement in the antioxidative defense of the organism bymelatonin supplementation in the examined group and may suggest melatonin supplementation as an additional treatment supporting hypotensive therapy in elderly EH patients. Expand
Melatonin prevents neutrophil‐mediated oxidative injury in Escherichia coli‐induced pyelonephritis in rats
TLDR
The protective effects of melatonin can be ascribed to its ability to inhibit neutrophil infiltration, to balance the oxidant–antioxidant status, and to regulate the generation of inflammatory mediators, suggesting a future role for melatonin in the treatment of acute pyelonephritis. Expand
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