Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats

  title={Melatonin attenuates methotrexate‐induced oxidative stress and renal damage in rats},
  author={Premila Abraham and Viswa Kalyan Kolli and Suganthy Rabi},
  journal={Cell Biochemistry and Function},
Nephrotoxicity is an adverse side effect of methotrexate (MTX) chemotherapy. The present study verifies whether melatonin, an endogenous antioxidant prevents MTX‐induced renal damage. Adult rats were administered 7 mg/kg body weight MTX intraperitoneally for 3 days. In the melatonin pretreated rats, 40 mg/ kg body weight melatonin was administered daily intraperitoneally 1 h before the administration of MTX. The rats were killed 12 h after the final dose of MTX/vehicle. The kidneys were used… 

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