Melatonin attenuates impairments of structural hippocampal neuroplasticity in OXYS rats during active progression of Alzheimer's disease-like pathology.

@article{Stefanova2015MelatoninAI,
  title={Melatonin attenuates impairments of structural hippocampal neuroplasticity in OXYS rats during active progression of Alzheimer's disease-like pathology.},
  author={Natalia A. Stefanova and Kseniya Yi. Maksimova and Elena V. Kiseleva and Ekaterina A. Rudnitskaya and Natalia A. Muraleva and Nataliya G. Kolosova},
  journal={Journal of pineal research},
  year={2015},
  volume={59 2},
  pages={
          163-77
        }
}
Translational research on Alzheimer's disease (AD) has often focused on reducing the high cerebral levels of amyloid-β (Aβ) as a key characteristic of AD pathogenesis. There is, however, a growing body of evidence that synaptic dysfunction may be crucial for the development of the most common (sporadic) form of AD. The applicability of melatonin (mainly produced by the pineal gland) to the treatment of AD is actively evaluated, but usually, such studies are based on animal models of early-onset… CONTINUE READING
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