Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/ CCL20 in glioma

@inproceedings{Chen2017MelatoninAH,
  title={Melatonin attenuates hypoxia-induced epithelial-mesenchymal transition and cell aggressive via Smad7/ CCL20 in glioma},
  author={Xueran Chen and Zhen Wang and Huihui Ma and Shangrong Zhang and Haoran Yang and Hailiang Wang and Zhiyou Fang},
  booktitle={Oncotarget},
  year={2017}
}
Tumor recurrence in gliomas is partly attributed to increased epithelial-mesenchymal transition (EMT) and enhanced tumor cell dissemination in the adjacent brain parenchyma. Thus, exploring effective strategies for against EMT-like changes in glioma invasion and recurrence will be important for glioma treatment. In this study, we investigated the roles of melatonin in hypoxia-induced EMT suppression, and found that melatonin could significantly suppress the release of the cytokine, CCL20, from… CONTINUE READING
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