Melatonin as immunomodulator in immunodeficient mice.

@article{Caroleo1992MelatoninAI,
  title={Melatonin as immunomodulator in immunodeficient mice.},
  author={Maria Cristina Caroleo and Daniela Frasca and Giuseppe Nistic{\'o} and G. Doria},
  journal={Immunopharmacology},
  year={1992},
  volume={23 2},
  pages={81-9}
}
Melatonin, the main hormone of the pineal gland, when chronically injected into young mice or mice immunodepressed by aging or by cyclophosphamide treatment, is able to enhance the antibody response to a T-dependent antigen. The enhancement of the antibody response is associated with increased induction of T helper cell activity and IL-2 production, as evidenced in mice immunodepressed by aging or by cyclophosphamide treatment. These observations suggest that melatonin treatment may be… CONTINUE READING

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