Melatonin as an antioxidant: under promises but over delivers

@article{Reiter2016MelatoninAA,
  title={Melatonin as an antioxidant: under promises but over delivers},
  author={R. Reiter and J. Mayo and D. Tan and R. Sainz and M. Alatorre‐Jim{\'e}nez and Lilian Qin},
  journal={Journal of Pineal Research},
  year={2016},
  volume={61}
}
Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large number of circumstances. It achieves this action via a variety of means: direct detoxification of reactive oxygen and reactive nitrogen species and indirectly by stimulating antioxidant enzymes while suppressing the activity of pro‐oxidant enzymes. In addition to these well‐described actions, melatonin also reportedly chelates transition metals, which are involved in the Fenton/Haber–Weiss reactions; in… Expand
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