Melatonin as a new possible anti-inflammatory agent.

@article{Lissoni1997MelatoninAA,
  title={Melatonin as a new possible anti-inflammatory agent.},
  author={Paolo Lissoni and Franco Rovelli and Sofia Meregalli and Luca Fumagalli and Flavia Musco and Ferdinando Brivio and Olimpio Brivio and G. Degli Esposti},
  journal={Journal of biological regulators and homeostatic agents},
  year={1997},
  volume={11 4},
  pages={
          157-9
        }
}
Several experiments have suggested that the pineal hormone melatonin (MLT) may regulate cancer growth by exerting both oncostatic and immunomodulating effects. In particular, MLT would stimulate the anticancer immunity induced by interleukin-2 (IL-2). Recent studies seem to suggest that the activation of the inflammatory response may counteract the anticancer efficacy of IL-2 immunotherapy because of the immunosuppressive action of inflammatory-related cytokines, mainly IL-6. At present, it is… CONTINUE READING

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The pineal regulation of the immune system: 40 years since the discovery.

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