Melatonin as a mitochondria-targeted antioxidant: one of evolution’s best ideas

@article{Reiter2017MelatoninAA,
  title={Melatonin as a mitochondria-targeted antioxidant: one of evolution’s best ideas},
  author={Russel Joseph Reiter and Sergio A. Rosales‐Corral and Dun-Xian Tan and Mei-Jie Jou and Annia Galano and Bing-yuan Xu},
  journal={Cellular and Molecular Life Sciences},
  year={2017},
  volume={74},
  pages={3863-3881}
}
Melatonin is an ancient antioxidant. After its initial development in bacteria, it has been retained throughout evolution such that it may be or may have been present in every species that have existed. Even though it has been maintained throughout evolution during the diversification of species, melatonin’s chemical structure has never changed; thus, the melatonin present in currently living humans is identical to that present in cyanobacteria that have existed on Earth for billions of years… 
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TLDR
The biosynthetic pathway characteristics of animal and plant cells have been compared, and the main differences between the two systems highlighted and the potential pharmacological and biostimulant benefits derived from the administration of exogenous melatonin on animals or plants via the intake of dietary supplements or the application of biostIMulant formulation have been largely discussed.
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