Melatonin as a Chronobiotic: Treatment of Circadian Desynchrony in Night Workers and the Blind

@article{Sack1997MelatoninAA,
  title={Melatonin as a Chronobiotic: Treatment of Circadian Desynchrony in Night Workers and the Blind},
  author={Robert Sack and Alfred J. Lewy},
  journal={Journal of Biological Rhythms},
  year={1997},
  volume={12},
  pages={595 - 603}
}
  • R. Sack, A. Lewy
  • Published 1 December 1997
  • Medicine
  • Journal of Biological Rhythms
Although the causes are different, totally blind people (without light perception) and night shift workers have in common recurrent bouts of insomnia and wake-time sleepiness that occur when their preferred (or mandated) sleep and wake times are out of synchrony with their endogenous circadian rhythms. In this article, the patterns of circadian desynchrony in these two populations are briefly reviewed with special emphasis on longitudinal studies in individual subjects that used the timing of… Expand
ENTRAINMENT OF FREE-RUNNING CIRCADIAN RHYTHMS BY MELATONIN IN BLIND PEOPLE
A BSTRACT Background Most totally blind people have circadian rhythms that are “free-running” (i.e., that are not synchronized to environmental time cues and that oscillate on a cycle slightly longerExpand
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Exogenous melatonin has been shown to entrain the clock in individuals with no light perception and free-running circadian rhythms, and studies have reported beneficial effects of melatonin for treatment of certain insomnias. Expand
Melatonin administration can entrain the free-running circadian system of blind subjects.
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In mammals, melatonin plasma levels are high during darkness at night and low during the day. Even in an environment free of time cues and in constant dim light, melatonin continues to express itsExpand
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TLDR
Melatonin, given several hours before its endogenous peak at night, effectively advances sleep time in DSPS and adjusts the sleep-wake cycle to 24 hours in blind individuals, and melatonin replacement therapy may provide a rational approach to the treatment of age-related insomnia in the elderly. Expand
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TLDR
Exogenous melatonin can act as soporific agent, a chronohypnotic, and/or a chronobiotic in order to treat sleep or circadian rhythm disorders. Expand
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TLDR
There appears to be a role of endogenous melatonin in the pathophysiology of these circadian rhythm sleep disorders and exogenous melatonin is useful in treating the disturbed sleep-wake rhythms seen in DSPS, Non 24 hr sleep/wake rhythm, Shift-work sleep disorder, jet lag and in depression. Expand
The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders
TLDR
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Melatonin as a chronobiotic.
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Successful use of melatonin's chronobiotic properties has been reported in other sleep disorders associated with abnormal timing of the circadian system: jetlag, shiftwork, delayed sleep phase syndrome, some sleep problems of the elderly. Expand
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References

SHOWING 1-10 OF 37 REFERENCES
Free-Running Melatonin Rhythms in Blind People: Phase Shifts with Melatonin and Triazolam Administration
TLDR
Since the plasma melatonin rhythm is not influenced by stress and is an excellent marker for the rhythm of the circadian pacemaker in the hypothalamus, it offers a valuable strategy for studying circadian rhythms in humans, including the blind. Expand
Circadian rhythm abnormalities in totally blind people: incidence and clinical significance.
TLDR
The high incidence of abnormal circadian rhythms in blind people underscores the importance of the light-dark cycle as an important environmental synchronizer for the human circadian system. Expand
Suppression of melatonin secretion in some blind patients by exposure to bright light.
TLDR
The visual subsystem that mediates light-induced suppression of melatonin secretion remains functionally intact in some sightless patients, and constitutes a distinct form of blindness, associated with periodic insomnia, that afflicts most but not all patients with no conscious perception of light. Expand
Melatonin Administration to Blind People: Phase Advances and Entrainment
TLDR
The purpose of this study was to test the phase-shifting and entraining effects of melatonin in human subjects, and found five totally blind men found to have free-running endogenous melatonin rhythms to be remarkably stable. Expand
Melatonin rhythms in night shift workers.
TLDR
In night shift workers, sleep was initiated about three hours prior to the onset of melatonin production, compared to day-active subjects, which suggests that the sleep times selected by nightshift workers may not be well-synchronized to their melatonin rhythm. Expand
Circadian sleep regulation in the absence of light perception: chronic non-24-hour circadian rhythm sleep disorder in a blind man with a regular 24-hour sleep-wake schedule.
TLDR
The findings in this blind man suggest that both his sleep structure and the severity of his daily sleep disruption are directly related to circadian phase and his circadian pacemaker cannot be entrained by periodic daily exposure to nonphotic time cues, including a very regular 24-hour sleep-wake schedule. Expand
Different Types of Melatonin Circadian Secretory Rhythms in Some Blind Subjects
TLDR
It is suggested that the light-dark cycle may be important in the regulation of the human melatonin circadian secretory rhythm and the endocrinological consequences of blindness as well as on the biological effects of light in humans. Expand
The circadian melatonin and cortisol secretion pattern in permanent night shift workers.
TLDR
The data collected suggest that even permanent night workers with a high degree of work satisfaction do not usually lose the diurnal orientation of their endogenous clock. Expand
FREE‐RUNNING CIRCADIAN PLASMA CORTISOL RHYTHM IN A BLIND HUMAN SUBJECT
TLDR
It is concluded that environment dark/light phase shifts are the dominant synchronizer of the circadian rhythm in plasma cortisol concentrations in man, as they are for a variety of circadian rhythms in other living things. Expand
Sleep propensity free-runs with the temperature, melatonin and cortisol rhythms in a totally blind person.
TLDR
The sleep propensity rhythm (as defined by an ultrashort sleep-wake schedule) free-ran with the melatonin, temperature and cortisol rhythms in a 44-year-old totally blind man even though he maintained a conventional sleep schedule and did not complain of clinically significant insomnia or excessive daytime sleepiness. Expand
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