Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms.

@article{Hardeland2013MelatoninAT,
  title={Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms.},
  author={R{\"u}diger Hardeland},
  journal={Journal of pineal research},
  year={2013},
  volume={55 4},
  pages={325-56}
}
The classic theories of aging such as the free radical theory, including its mitochondria-related versions, have largely focused on a few specific processes of senescence. Meanwhile, numerous interconnections have become apparent between age-dependent changes previously thought to proceed more or less independently. Increased damage by free radicals is not only linked to impairments of mitochondrial function, but also to inflammaging as it occurs during immune remodeling and by release of… CONTINUE READING
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