Melatonin and the immune system in aging.

  title={Melatonin and the immune system in aging.},
  author={Daniel P. Cardinali and Ana Isabel Esquifino and Venkataramanujan Srinivasan and Seithikurippu R Pandi-Perumal},
  volume={15 4-6},
Aging is associated with a decline in immune function (immunosenescence), a condition known to correlate with increased incidence of cancer as well as infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. Circulating melatonin decreases with age, and in recent years much interest has been focused on its immunomodulatory effect. Melatonin stimulates the production of progenitor cells for granulocytes and macrophages. It also… CONTINUE READING

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