Melatonin and radioprotection from genetic damage: in vivo/in vitro studies with human volunteers.

@article{Vijayalaxmi1996MelatoninAR,
  title={Melatonin and radioprotection from genetic damage: in vivo/in vitro studies with human volunteers.},
  author={Vijayalaxmi and Russell J Reiter and Terence S. Herman and Martin L. Meltz},
  journal={Mutation research},
  year={1996},
  volume={371 3-4},
  pages={221-8}
}
Peripheral blood samples were collected from human volunteers at 0 (5-10 min before), and at 1 and 2 h after a single oral dose of 300 mg of melatonin. At each time point, (i) the concentration of melatonin in the serum and in the leukocytes was determined, and (ii) the whole blood was exposed in vitro to 150 cGy of 137Cs gamma radiation, and the lymphocytes were cultured with mitogenic stimulation to determine the extent of radiation-induced genetic damage, viz, chromosome aberrations and… CONTINUE READING