Melatonin and melatonergic drugs on sleep: possible mechanisms of action.

  title={Melatonin and melatonergic drugs on sleep: possible mechanisms of action.},
  author={Venkataramanujan Srinivasan and Seithikurippu R Pandi-Perumal and Ilya Trahkt and David Warren Spence and Burkhard Poeggeler and R{\"u}diger Hardeland and Daniel P. Cardinali},
  journal={The International journal of neuroscience},
  volume={119 6},
Pineal melatonin is synthesized and secreted in close association with the light/dark cycle. The temporal relationship between the nocturnal rise in melatonin secretion and the "opening of the sleep gate" (i.e., the increase in sleep propensity at the beginning of the night), coupled with the sleep-promoting effects of exogenous melatonin, suggest that melatonin is involved in the regulation of sleep. The sleep-promoting and sleep/wake rhythm regulating effects of melatonin are attributed to… CONTINUE READING