Melatonin and its receptor MT1 are involved in the downstream reaction to luteinizing hormone and participate in the regulation of luteinization in different species.

@article{He2016MelatoninAI,
  title={Melatonin and its receptor MT1 are involved in the downstream reaction to luteinizing hormone and participate in the regulation of luteinization in different species.},
  author={Changjiu He and Teng Ma and Jianmin Shi and Zhenzhen Zhang and Jing Wang and Kuanfeng Zhu and Yu Hang Li and Minghui Yang and Yukun Song and Guoshi Liu},
  journal={Journal of pineal research},
  year={2016},
  volume={61 3},
  pages={279-90}
}
The functions of melatonin in preovulatory fluid remain elusive. In the current study, we observed that the extremely high level of expression of MT1 in mice granulosa cells was rapidly induced by hCG (equivalent LH) within 2 hours and this was referred as MT1 surge. In cumulus cells, serotonin N-acetyltransferase (SNAT) was also upregulated by hCG and led to elevated melatonin levels in ovarian follicle fluid. Melatonin application before MT1 surge significantly promoted embryo implantation… CONTINUE READING
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