Melatonin and human reproduction: Shedding light on the darkness hormone

  title={Melatonin and human reproduction: Shedding light on the darkness hormone},
  author={Venkatramanujam Srinivasan and Warren Spence and Seithikurippu R. Pandi-Perumal and Rahima Zakharia and Kunwar P. Bhatnagar and Amnon Brzezinski},
  journal={Gynecological Endocrinology},
  pages={779 - 785}
Melatonin, N-acetyl-5-methoxytryptamine, is a molecule with diverse physiological functions. This neuro-hormone affects reproductive performance in a wide variety of species. In most animals, but not exclusively all, melatonin has an antigonadotrophic effect. The seasonal changes in the number of hours per day that melatonin is secreted mediate the temporal coupling of reproductive activity to seasonal changes in day-length. These observations stimulated a search for a role for the pineal gland… 
Melatonin and animal reproduction: implications on ovarian physiology.
The melatonin influence in the animal reproduction, especially in the ovarian physiology, is reviewed, since high levels in follicular fluid were detected and the presence of melatonin receptors in the ovary cells has been found.
The melatonin influence in the animal reproduction, especially in the ovarian physiology, is reviewed, since high levels in follicular fluid were detected and the presence of melatonin receptors in the ovary cells has been found.
Melatonin, adolescence, and the brain: An insight into the period‐specific influences of a multifunctional signaling molecule
This review examines the influences of endogenous and exogenous melatonin on the adolescent brain, with specific reference to its involvement in the evolution of brain functions, brain structure, sleep regulation, and modulation of behaviors in health or disease.
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For clinical trials, the direct effect of exogenous melatonin administration on patients manifested with cancer should be studied to find its oncostatic effects on some cancers and provide information on its dosage and long-term safety.
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The effects of melatonin on the reproductive function is analyzed as well as to shed light on immunological and oncostatic properties of one of the most powerful hormones.
Melatonin, the Hormone of Darkness: From Sleep Promotion to Ebola Treatment.
The potential utility of melatonin in the deadly modern-day Ebola epidemic is highlighted and this pleiotropic molecule has anti-inflammatory, antioxidant and anticoagulopathic properties in addition to its endothelial protective effects.
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A better understanding of environmental factors that affect melatonin and subsequent effects on physiological processes will allow clinicians to develop treatments and recommend modifiable behaviours to improve sleep, increase daytime alertness, and regulate ocular and systemic processes related to melatonin.
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    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
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The basic data on melatonin significance in human physiology and in pathological processes as well as its possible therapeutic significance are reviewed and discussed.
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Findings render unlikely the inference that the pineal gland has no role in the development and function of the human reproductive axis and suggest that a pineal‐puberty relation does exist in humans.
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It is proposed that melatonin acts in the developing animal as a regulator of internal synchrony between tissues and response elements for transcription factors involved in both pituitary differentiation and gonadotroph regulation are found.
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The hormonal activity of the pineal gland is influenced by both the dark-light cycle and the seasonal cycle, causing it to play an important role in the neuroendocrine control of reproductive
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Indoleamine at the level of the central nervous system is a modulation of GnRH secretion but it does not act directly on GnRH neurones; rather, its action involves a complex neural circuit of interneurones that includes at least dopaminergic, serotoninergic and aminoacidergic neurones.
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A melatonin-based contraceptive that blocks luteinizing hormone and follicle-stimulating hormone is now in Phase III clinical trials and its application to the development of a non-steroidal contraceptive is introduced.
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A multifactorial analysis of variance showed that, in addition to the well-established increases of gonadotropins at midcycle andmelatonin and prolactin at night, there was a significant effect of season on the serum levels of melatonin and LH.
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It is found that melatonin is a very potent hydroxyl radical scavenger and there is evidence that it may be bound in the nucleus thereby providing on-site protection to DNA.