Melatonin and human reproduction: Shedding light on the darkness hormone

@article{Srinivasan2009MelatoninAH,
  title={Melatonin and human reproduction: Shedding light on the darkness hormone},
  author={Venkatramanujam Srinivasan and W. Spence and S. Pandi-Perumal and Rahima Zakharia and K. P. Bhatnagar and A. Brzezinski},
  journal={Gynecological Endocrinology},
  year={2009},
  volume={25},
  pages={779 - 785}
}
Melatonin, N-acetyl-5-methoxytryptamine, is a molecule with diverse physiological functions. This neuro-hormone affects reproductive performance in a wide variety of species. In most animals, but not exclusively all, melatonin has an antigonadotrophic effect. The seasonal changes in the number of hours per day that melatonin is secreted mediate the temporal coupling of reproductive activity to seasonal changes in day-length. These observations stimulated a search for a role for the pineal gland… Expand
Melatonin and animal reproduction: implications on ovarian physiology.
TLDR
The melatonin influence in the animal reproduction, especially in the ovarian physiology, is reviewed, since high levels in follicular fluid were detected and the presence of melatonin receptors in the ovary cells has been found. Expand
MELATONINA E REPRODUÇÃO ANIMAL: IMPLICAÇÕES NA
TLDR
The melatonin influence in the animal reproduction, especially in the ovarian physiology, is reviewed, since high levels in follicular fluid were detected and the presence of melatonin receptors in the ovary cells has been found. Expand
Melatonin, adolescence, and the brain: An insight into the period‐specific influences of a multifunctional signaling molecule
TLDR
This review examines the influences of endogenous and exogenous melatonin on the adolescent brain, with specific reference to its involvement in the evolution of brain functions, brain structure, sleep regulation, and modulation of behaviors in health or disease. Expand
Melatonin: An Introduction to Its Physiological and Pharmacological Effects in Humans
Melatonin is a methoxyindole that, under normal environmental conditions, is synthesized and secreted principally by the pineal gland at night. The endogenous rhythm of secretion is generated by theExpand
Melatonin and Its Indisputable Effects on the Health State
TLDR
For clinical trials, the direct effect of exogenous melatonin administration on patients manifested with cancer should be studied to find its oncostatic effects on some cancers and provide information on its dosage and long-term safety. Expand
Melatonin: a “Higgs boson” in human reproduction
TLDR
The effects of melatonin on the reproductive function is analyzed as well as to shed light on immunological and oncostatic properties of one of the most powerful hormones. Expand
Melatonin, the Hormone of Darkness: From Sleep Promotion to Ebola Treatment.
TLDR
The potential utility of melatonin in the deadly modern-day Ebola epidemic is highlighted and this pleiotropic molecule has anti-inflammatory, antioxidant and anticoagulopathic properties in addition to its endothelial protective effects. Expand
Ocular and systemic melatonin and the influence of light exposure
TLDR
A better understanding of environmental factors that affect melatonin and subsequent effects on physiological processes will allow clinicians to develop treatments and recommend modifiable behaviours to improve sleep, increase daytime alertness, and regulate ocular and systemic processes related to melatonin. Expand
Agomelatine, Melatonin and Depression
TLDR
A review of findings relating possible melatonin abnormalities in major depressive disorder as well as the action of melatonin and newer melatonin selective agonists as antidepressants is presented, suggesting that additional pharmacological actions are an essential requirement for a molecule to demonstrate antidepressant effects in the clinic. Expand
Current role of melatonin in pediatric neurology: clinical recommendations.
TLDR
Animal work and limited human data suggest that melatonin does not exacerbate seizures and might decrease them, and animal work has confirmed a neuroprotective effect of melatonin, suggesting a role in minimising neuronal damage from birth asphyxia. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 91 REFERENCES
Neuroendocrinology of melatonin in reproduction: recent developments
TLDR
The recent demonstration of 2[125I]iodomelatonin binding sites or melatonin receptors in the testis, epididymis, vas deferens, prostate, ovary and mammary gland suggest the concept of multiple sites of melatonin action on the reproductive system. Expand
Melatonin and pregnancy in the human.
TLDR
Melatonin is a neuroendocrine hormone secreted nightly by pineal gland and regulates biological rhythms and it appears to be essential for successful pregnancy. Expand
Melatonin and human puberty: Current perspectives
  • A. Cavallo
  • Biology, Medicine
  • Journal of pineal research
  • 1993
TLDR
Findings render unlikely the inference that the pineal gland has no role in the development and function of the human reproductive axis and suggest that a pineal‐puberty relation does exist in humans. Expand
Melatonin Action in the Pituitary: Neuroendocrine Synchronizer and Developmental Modulator?
TLDR
It is proposed that melatonin acts in the developing animal as a regulator of internal synchrony between tissues and response elements for transcription factors involved in both pituitary differentiation and gonadotroph regulation are found. Expand
The pineal gland and reproduction.
The hormonal activity of the pineal gland is influenced by both the dark-light cycle and the seasonal cycle, causing it to play an important role in the neuroendocrine control of reproductiveExpand
Biology of Mammalian Photoperiodism and the Critical Role of the Pineal Gland and Melatonin
TLDR
Indoleamine at the level of the central nervous system is a modulation of GnRH secretion but it does not act directly on GnRH neurones; rather, its action involves a complex neural circuit of interneurones that includes at least dopaminergic, serotoninergic and aminoacidergic neurones. Expand
Melatonin and the human gonadotrophin-releasing hormone pulse generator.
  • R. Silman
  • Biology, Medicine
  • The Journal of endocrinology
  • 1991
TLDR
A melatonin-based contraceptive that blocks luteinizing hormone and follicle-stimulating hormone is now in Phase III clinical trials and its application to the development of a non-steroidal contraceptive is introduced. Expand
Seasonal, menstrual and circadian secretions of melatonin, gonadotropins and prolactin in women.
TLDR
A multifactorial analysis of variance showed that, in addition to the well-established increases of gonadotropins at midcycle andmelatonin and prolactin at night, there was a significant effect of season on the serum levels of melatonin and LH. Expand
Interactions of the pineal hormone melatonin with oxygen-centered free radicals: a brief review.
  • R. Reiter
  • Biology, Medicine
  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 1993
TLDR
It is found that melatonin is a very potent hydroxyl radical scavenger and there is evidence that it may be bound in the nucleus thereby providing on-site protection to DNA. Expand
The pineal gland: its possible roles in human reproduction.
TLDR
It is suggested that abnormal patterns of melatonin might be associated with amenorrhea, anovulation, unexplained infertility, premature menopause, and habitual abortions. Expand
...
1
2
3
4
5
...