Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives.

  title={Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives.},
  author={Stephen G. Grant and Melissa A. Melan and Jean J. Latimer and Paula A Witt-Enderby},
  journal={Expert reviews in molecular medicine},
Recent studies have suggested that the pineal hormone melatonin may protect against breast cancer, and the mechanisms underlying its actions are becoming clearer. Melatonin works through receptors and distinct second messenger pathways to reduce cellular proliferation and to induce cellular differentiation. In addition, independently of receptors melatonin can modulate oestrogen-dependent pathways and reduce free-radical formation, thus preventing mutation and cellular toxicity. The fact that… CONTINUE READING
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