Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon

@inproceedings{Peschke2013MelatoninAP,
  title={Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon},
  author={Elmar Peschke and Ina B{\"a}hr and Eckhard M{\"u}hlbauer},
  booktitle={International journal of molecular sciences},
  year={2013}
}
The pineal hormone melatonin exerts its influence in the periphery through activation of two specific trans-membrane receptors: MT1 and MT2. Both isoforms are expressed in the islet of Langerhans and are involved in the modulation of insulin secretion from β-cells and in glucagon secretion from α-cells. De-synchrony of receptor signaling may lead to the development of type 2 diabetes. This notion has recently been supported by genome-wide association studies identifying particularly the MT2 as… CONTINUE READING
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