Melatonin and Associated Signaling Pathways that Control Normal Breast Epithelium and Breast Cancer

@article{Hill2011MelatoninAA,
  title={Melatonin and Associated Signaling Pathways that Control Normal Breast Epithelium and Breast Cancer},
  author={Steven Marc Hill and David E. Blask and Shulin Xiang and Lin Yuan and Lulu Mao and Robert T. Dauchy and Erin M. Dauchy and Tripp Frasch and Tamika Duplesis},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={2011},
  volume={16},
  pages={235-245}
}
This review article discusses recent work on the melatonin-mediated circadian regulation and integration of molecular and metabolic signaling mechanisms involved in human breast cancer growth and the associated consequences of circadian disruption by exposure to light-at-night (LAN). The anti-proliferative effects of the circadian melatonin signal are, in general, mediated through mechanisms involving the activation of MT1 melatonin receptors expressed in human breast cancer cell lines and… CONTINUE READING

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