Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicity.

@article{Maharaj2006MelatoninA6,
  title={Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicity.},
  author={Deepa S. Maharaj and Himant Maharaj and Santy Daya and Beverley Dawn Glass},
  journal={Journal of neurochemistry},
  year={2006},
  volume={96 1},
  pages={78-81}
}
Oxidative damage of biological macromolecules is a hallmark of most neurodegenerative disorders such as Alzheimer, Parkinson and diffuse Lewy body diseases. Another important phenomenon involved in these disorders is the alteration of iron homeostasis, with an increase in iron levels. The present study investigated whether 6-hydroxymelatonin (6-OHM) can reduce Fe2+-induced lipid peroxidation and necrotic cell damage in the rat hippocampus in vivo. It was found that 6-OHM administration proved… CONTINUE READING
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