Melatonin ameliorates oxidative stress and reproductive toxicity induced by cyclophosphamide in male mice.

@article{Chabra2014MelatoninAO,
  title={Melatonin ameliorates oxidative stress and reproductive toxicity induced by cyclophosphamide in male mice.},
  author={Aroona Chabra and Mohammad Shokrzadeh and Farshad Naghshvar and Fatemeh Salehi and Abbas Ahmadi},
  journal={Human & experimental toxicology},
  year={2014},
  volume={33 2},
  pages={185-95}
}
The present study evaluated the efficacy of melatonin in cyclophosphamide (CP)-induced testicular injury, lipid peroxidative damage, and antioxidant enzymes status of the mice testis on the basis of biochemical and histological studies. Mice were pretreated with four different doses of melatonin (2.5, 5, 10, and, 20 mg/kg by body weight (b.w.)) via intraperitoneal injection for five consecutive days followed by injection with CP (200 mg/kg b.w.) 1 h after the last injection of melatonin on the… CONTINUE READING

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