Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction.

@article{Quiroz2008MelatoninAO,
  title={Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction.},
  author={Yasmir J. Quiroz and Atilio Ferrebuz and Freddy Romero and Nosratola D. Vaziri and Bernardo Rodriguez-Iturbe},
  journal={American journal of physiology. Renal physiology},
  year={2008},
  volume={294 2},
  pages={F336-44}
}
The progressive deterioration of renal function and structure resulting from renal mass reduction are mediated by a variety of mechanisms, including oxidative stress and inflammation. Melatonin, the major product of the pineal gland, has potent_antioxidant and anti-inflammatory properties, and its production is impaired in chronic renal failure. We therefore investigated if melatonin treatment would modify the course of chronic renal failure in the remnant kidney model. We studied rats followed… CONTINUE READING

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