Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling

@inproceedings{Yu2017MelatoninAM,
  title={Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling},
  author={Liming Yu and Bing Gong and Weixun Duan and Chongxi Fan and Jian Zhang and Zhi Li and Xiaodong Xue and Yinli Xu and Dandan Meng and Buying Li and Meng Zhang and Bin Zhang and Zhenxiao Jin and Shiqiang Yu and Yang Yang and Huishan Wang},
  booktitle={Scientific reports},
  year={2017}
}
Enhancing mitochondrial biogenesis and reducing mitochondrial oxidative stress have emerged as crucial therapeutic strategies to ameliorate diabetic myocardial ischemia/reperfusion (MI/R) injury. Melatonin has been reported to be a safe and potent cardioprotective agent. However, its role on mitochondrial biogenesis or reactive oxygen species (ROS) production in type 1 diabetic myocardium and the underlying mechanisms remain unknown. We hypothesize that melatonin ameliorates MI/R injury in type… CONTINUE READING
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