Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.

  title={Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.},
  author={Jianqiang Hu and Lei Zhang and Yang Yang and Yanjie Guo and Yanhong Fan and Mingming Zhang and Wanrong Man and E. Mei Gao and Wei Hu and Russell J Reiter and Haichang Wang and Dongdong Sun},
  journal={Journal of pineal research},
  volume={62 1}
Melatonin reportedly protects against several cardiovascular diseases including ischemia/reperfusion (I/R), atherosclerosis, and hypertension. The present study investigated the effects and mechanisms of melatonin on cardiomyocyte autophagy, apoptosis, and mitochondrial injury in the context of myocardial infarction (MI). We demonstrated that melatonin significantly alleviated cardiac dysfunction after MI. Four weeks after MI, echocardiography and Masson staining indicated that melatonin… CONTINUE READING
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