Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome.

@article{Cao2017MelatoninAC,
  title={Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome.},
  author={Zhengwang Cao and Y Fang and Yonghui Lu and Dunxian Tan and Changhong Du and Yu-ming Li and Qinlong Ma and Junmei Yu and Mengyan Chen and Chao Zhou and Liping Pei and Lei Zhang and Haiying Ran and Mindi He and Zheng-ping Yu and Zhou Zhou},
  journal={Journal of pineal research},
  year={2017},
  volume={62 3}
}
Cadmium (Cd) is a persistent environmental and occupational contaminant that accumulates in the liver and induces oxidative stress and inflammation. Melatonin possesses potent hepatoprotective properties against the development and progression of acute and chronic liver injury. Nevertheless, the molecular mechanism underlying the protective effects of melatonin against Cd-induced hepatotoxicity remains obscure. In this study, we aimed to investigate the effects of melatonin on Cd-induced liver… CONTINUE READING
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