Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes.

@article{Ji2012MelatoninAC,
  title={Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes.},
  author={Yan-Li Ji and Hua Wang and Can Meng and Xian-feng Zhao and Cheng Zhang and Ying Zhang and Mei Ping Zhao and Yuan-hua Chen and Xiu Hong Meng and De-Xiang Xu},
  journal={Journal of pineal research},
  year={2012},
  volume={52 1},
  pages={71-9}
}
Increasing evidence demonstrates that melatonin has an anti-apoptotic effect in somatic cells. However, whether melatonin can protect against germ cell apoptosis remains obscure. Cadmium (Cd) is a testicular toxicant and induces germ cell apoptosis. In this study, we investigated the effects of melatonin on Cd-evoked germ cell apoptosis in testes. Male ICR mice were intraperitoneally (i.p.) injected with melatonin (5 mg/kg) every 8 hr, beginning at 8 hr before CdCl(2) (2.0 mg/kg, i.p.). As… CONTINUE READING
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