Melatonin alleviates aluminium chloride-induced immunotoxicity by inhibiting oxidative stress and apoptosis associated with the activation of Nrf2 signaling pathway.

@article{Yu2019MelatoninAA,
  title={Melatonin alleviates aluminium chloride-induced immunotoxicity by inhibiting oxidative stress and apoptosis associated with the activation of Nrf2 signaling pathway.},
  author={Hongyang Yu and Jian Zhang and Qiang Ji and Kaiyuan Yu and Peiyan Wang and Miao Song and Zheng Cao and Xueyan Zhang and Yanfei Li},
  journal={Ecotoxicology and environmental safety},
  year={2019},
  volume={173},
  pages={
          131-141
        }
}
The present study aimed to investigate whether melatonin (MT) treatment can attenuate immunotoxicity induced by aluminum chloride (AlCl3) in rat spleen. Forty-eight healthy male Wistar rats were randomly allocated and treated with AlCl3 and/or MT. Rats were orally administered with AlCl3 for 90 days, from 61st days, rats were injected intraperitoneally with MT for 30 days. Firstly, we found that MT relieved the AlCl3-induced immunosuppression by improving spleen structural damage, CD3+ and CD4… Expand
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