Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials

@article{Rajaratnam2009MelatoninAT,
  title={Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials},
  author={Shantha M. W. Rajaratnam and M. H. Polymeropoulos and Dennis M. Fisher and Thomas Roth and Christine Scott and Gunther Birznieks and Elizabeth B. Klerman},
  journal={The Lancet},
  year={2009},
  volume={373},
  pages={482-491}
}

Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial

Melatonin treatment 1 h prior to DBT combined with behavioural sleep-wake scheduling was efficacious for improving objective and subjective measures of sleep disturbances and sleep-related impairments in DSWPD patients with delayed circadian phase relative to D BT.

Tasimelteon: a melatonin receptor agonist for non-24-hour sleep-wake disorder.

Tasimelteon improves sleep initiation and maintenance in patients with Non-24 who have a shift in endogenous circadian rhythms, however, the cost of this agent limits its use.

Efficacy of Tasimelteon (HETLIOZ®) in the Treatment of Jet Lag Disorder Evaluated in an 8-h Phase Advance Model; a Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

A single dose of tasimelteon improves the primary symptoms of Jet Lag Disorder, including nighttime insomnia and next day functioning among participants in a laboratory model of JLD simulating eastward trans-meridian travel by inducing an 8-h phase advance of the sleep-wake cycle.

Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals

People with Non-24 who received oral tasimelteon 20 mg once nightly were significantly more likely than those receiving placebo to entrain the circadian pacemaker and maintain entrainment in the RESET trial.

Tasimelteon (HETLIOZ®) effective in the treatment of Jet Lag Disorder in an 8-hour phase advance; a multicenter, randomized, double-blind, placebo-controlled trial

A single dose of tasimelteon improves symptoms, including sleep and next day functioning in participants, following an 8-h phase advance of the sleep-wake cycle in a laboratory model of JLD simulating eastward trans-meridian travel.

New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists

  • R. Hardeland
  • Psychology, Biology
    Neuropsychiatric disease and treatment
  • 2009
Despite otherwise good tolerability, the use of melatoninergic drugs in children, adolescents, and during pregnancy has been a matter of concern, and should be avoided in autoimmune diseases and Parkinsonism.

Tasimelteon for treating non-24-h sleep-wake rhythm disorder

Tasimelteon entrains circadian rhythms and improves the sleep-wake functions of individuals with non-24, and it is the only pharmacological therapy approved by the US Food and Drug Administration and the European Medicines Agency for non- 24.

Melatonergic agents influence the sleep-wake and circadian rhythms in healthy and psychiatric participants: a systematic review and meta-analysis of randomized controlled trials

Given the unmet clinical need for evidence-based treatments to correct circadian rhythms in psychiatric disorders, efficacy of melatonergic agents seen in healthy participants, and similarity of findings among psychiatric patients, large scale, well-designed randomized controlled trials are needed to test efficacy on circadian parameters in psychiatric Disorders.

Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies

Long-term tasimelteon administration was safe and well-tolerated, supported by placebo-controlled data in both Non-24 and insomnia patients.
...

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