Melatonin affords protection against gastric lesions induced by ischemia-reperfusion possibly due to its antioxidant and mucosal microcirculatory effects.

@article{Konturek1997MelatoninAP,
  title={Melatonin affords protection against gastric lesions induced by ischemia-reperfusion possibly due to its antioxidant and mucosal microcirculatory effects.},
  author={Peter C. Konturek and Stanisław Jan Konturek and Jolanta Majka and Marian Zembala and Eckhart Georg Hahn},
  journal={European journal of pharmacology},
  year={1997},
  volume={322 1},
  pages={73-7}
}
Melatonin, a pineal hormone, is known to scavenge oxygen free radicals and to be present in the gut but little is known about its role in the protection of gastric mucosa against the damage accompanied by a marked increase in these radicals. This study was designed to determine the effects of melatonin on the formation of acute gastric lesions induced by ischemia-reperfusion and, for comparison, by a topical irritant such as 100% ethanol. It was found that pretreatment with melatonin at a dose… CONTINUE READING
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