Melatonin Treatment Improves Mesenchymal Stem Cells Therapy by Preserving Stemness during Long-term In Vitro Expansion

@inproceedings{Shuai2016MelatoninTI,
  title={Melatonin Treatment Improves Mesenchymal Stem Cells Therapy by Preserving Stemness during Long-term In Vitro Expansion},
  author={Yi Shuai and Li Liao and Xiaoxia Su and Yonghao Yu and Bingyi Shao and Huan Jing and Xinjing Zhang and Zhi-hong Deng and Yan Jin},
  booktitle={Theranostics},
  year={2016}
}
Mesenchymal stem cells (MSCs) are promising candidates for tissue regeneration and disease treatment. However, long-term in vitro passaging leads to stemness loss of MSCs, resulting in failure of MSCs therapy. Here, we report a melatonin-based strategy to improve cell therapy of in vitro cultured MSCs. Among four small molecules with anti-aging and stem cell-protection properties (rapamycin, resveratrol, quercetin and melatonin), colony forming, proliferation, and osteogenic differentiation… CONTINUE READING

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