Melatonin Reduces Apoptosis Induced by Calcium Signaling in Human Leukocytes: Evidence for the Involvement of Mitochondria and Bax Activation

@article{Espino2010MelatoninRA,
  title={Melatonin Reduces Apoptosis Induced by Calcium Signaling in Human Leukocytes: Evidence for the Involvement of Mitochondria and Bax Activation},
  author={Javier Espino and Ing.Carlos Bejarano and Pedro Cosme Redondo and Juan Antonio Rosado and Carmen Carolina Aranda Barriga and Russell J. Reiter and Jos{\'e} Antonio Pariente and Ana Beatriz Mateos Rodr{\'i}guez},
  journal={Journal of Membrane Biology},
  year={2010},
  volume={233},
  pages={105-118}
}
We have evaluated the effect of melatonin on apoptosis evoked by increases in [Ca2+]c in human leukocytes. Our results show that treatment of neutrophils with the calcium mobilizing agonist FMLP or the specific inhibitor of calcium reuptake thapsigargin induced a transient increase in [Ca2+]c. Our results also show that FMLP and thapsigargin increased caspase-9 and -3 activities and the active forms of both caspases. The effect of FMLP and thapsigargin on caspase activation was time-dependent… CONTINUE READING
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References

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Calcium and apoptosis

G Hajnoczky, E Davis, M Madesh
  • Biochem Biophys Res Commun
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Calcium and apoptosis

G Hajnoczky, E Davis, M Madesh
  • Biochem Biophys Res Commun
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Melatonin: a potent, endogenous hydroxyl radical scavenger

DX Tan, LD Chen, B Poeggeler, LC Manchester, RJ Reiter
  • Endocrine J
  • 1993
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

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