Melatonin Prolonged Release

@article{LysengWilliamson2012MelatoninPR,
  title={Melatonin Prolonged Release},
  author={Katherine A. Lyseng-Williamson},
  journal={Drugs \& Aging},
  year={2012},
  volume={29},
  pages={911-923}
}
Melatonin prolonged release (PR) 2 mg is approved for the treatment of primary insomnia characterized by poor sleep quality in patients aged ≥55 years in the EU and elsewhere. Patients may receive treatment with melatonin PR for up to 13 weeks. Production of endogenous nocturnal melatonin, which helps regulate circadian rhythm, may be decreased in older adults. Administration of melatonin PR 2 mg 1–2 h before bedtime mimics the natural secretion pattern of melatonin, thereby leading to… 

Tables from this paper

Melatonin prolonged release: a guide to its use in the treatment of insomnia in patients aged ≥55 years
In patients with primary insomnia aged ≥55 years, melatonin prolonged release (PR) 2 mg 1–2 h before bedtime improves the circadian regulation of the sleep-wake cycle, leading to improvements in many
Melatonin Modified Release Formulations Designed for Sleep Disorders
  • M. Vlachou, A. Siamidi
  • Biology
    Melatonin - Molecular Biology, Clinical and Pharmaceutical Approaches
  • 2018
TLDR
This chapter covers the recent scientific work on melatonin modified release formulations and the beneficial effect of fast-release formulations on sleep initiation and the benefit of the sustained release systems comes from the release of melatonin in small dosages during the entire night period.
The use and misuse of exogenous melatonin in the treatment of sleep disorders
  • R. Riha
  • Medicine, Psychology
    Current opinion in pulmonary medicine
  • 2018
TLDR
There is evidence for the efficacy of melatonin in the management of insomnia and some intrinsic disorders of circadian rhythm in adults and children as well as in reducing sleep onset latency in jet-lag and shift work disorder in adults.
Sleep Disorders and Melatonin
TLDR
Melatonin is an endogenously produced neurohormone that plays a key role in the signaling of daily rhythms and the coordination of these rhythms with the external world and can be used to manipulate circadian phase and promote sleep in a circadian rhythm-dependent fashion.
Tasimelteon for treating non-24-h sleep-wake rhythm disorder
TLDR
Tasimelteon entrains circadian rhythms and improves the sleep-wake functions of individuals with non-24, and it is the only pharmacological therapy approved by the US Food and Drug Administration and the European Medicines Agency for non- 24.
Per Os Administered Modified-Release Solid Formulations of Melatonin: A Review of the Latest Developments Including the Design of Experiments (DoE) Approach
TLDR
A review of the related literature on the modified release of MLT from its per os administered formulations is presented, including the utilization of the design of experiments for the selection of the optimal composition of melatonin formulations.
Melatonergic Drug Ramelteon in Neurotherapeutics
TLDR
Melatonergic agonist ramelteon is used for treating autistic disorder and delirium where the drug has been found effective in not only alleviating the sleep disorders but also the behavioral problems.
Making sleep easier: pharmacological interventions for insomnia
TLDR
In this review, the authors highlight basic physiological pathways of sleep regulation to understand fundamental pharmacological principles of sleep medicine and suggest focusing subjective sleep disturbances, such as superficial sleep perception, might help identify novel pathways.
...
1
2
3
4
...

References

SHOWING 1-10 OF 45 REFERENCES
Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes
TLDR
PR-melatonin results in significant and clinically meaningful improvements in sleep quality, morning alertness, sleep onset latency and quality of life in primary insomnia patients aged 55 years and over.
Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety
TLDR
The results demonstrate short- and long-term efficacy and safety of PRM in elderly insomnia patients and low melatonin production regardless of age is not useful in predicting responses to melatonin therapy in insomnia.
Improvement of sleep quality by controlled-release melatonin in benzodiazepine-treated elderly insomniacs.
New approaches in the management of insomnia: weighing the advantages of prolonged-release melatonin and synthetic melatoninergic agonists
  • R. Hardeland
  • Psychology, Biology
    Neuropsychiatric disease and treatment
  • 2009
TLDR
Despite otherwise good tolerability, the use of melatoninergic drugs in children, adolescents, and during pregnancy has been a matter of concern, and should be avoided in autoimmune diseases and Parkinsonism.
The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia
Objectives of this study were to investigate the effects of prolonged-release melatonin 2 mg (PRM) on sleep and subsequent daytime psychomotor performance in patients aged ≥55 years with primary
Prolonged‐release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects
TLDR
PR‐melatonin is the first drug shown to significantly improve quality of sleep and morning alertness in primary insomnia patients aged 55’years and older, suggesting more restorative sleep, and without withdrawal symptoms upon discontinuation.
Prolonged release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for short- and long-term response
TLDR
Short- and long-term efficacy of PRM in insomnia patients aged 18–80 years, particularly those aged 55 and over are demonstrated, and PRM was well-tolerated over the entire 6-month period with no rebound or withdrawal symptoms following discontinuation.
Role of the Melatonin System in the Control of Sleep
TLDR
The hypnotic and rhythm-regulating properties of melatonin and its agonists make them an important addition to the armamentarium of drugs for treating primary and secondary insomnia and circadian rhythm sleep disorders.
...
1
2
3
4
5
...