Melatonin Metabolism in the Central Nervous System

  title={Melatonin Metabolism in the Central Nervous System},
  author={R{\"u}diger Hardeland},
  booktitle={Current neuropharmacology},
The metabolism of melatonin in the central nervous system is of interest for several reasons. Melatonin enters the brain either via the pineal recess or by uptake from the blood. It has been assumed to be also formed in some brain areas. Neuroprotection by melatonin has been demonstrated in numerous model systems, and various attempts have been undertaken to counteract neurodegeneration by melatonin treatment. Several concurrent pathways lead to different products. Cytochrome P(450) subforms… CONTINUE READING
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