Melatonin Enters the Cerebrospinal Fluid through the Pineal Recess.

@article{Tricoire2002MelatoninET,
  title={Melatonin Enters the Cerebrospinal Fluid through the Pineal Recess.},
  author={He le Ne Tricoire and Alain Locatelli and Philippe Chemineau and Benoi T Malpaux},
  journal={Endocrinology},
  year={2002},
  volume={143 1},
  pages={84-90}
}
The pineal recess (PR), a third ventricle (IIIV) evagination penetrating into the pineal gland, could constitute a site of melatonin passage to the cerebrospinal fluid (CSF) and explain the high concentrations of melatonin in this fluid. To test this hypothesis, we characterized melatonin distribution in the IIIV of sheep by CSF collection in the ventral part of IIIV (vIIIV) and in PR. At 30 l/min collection rate, melatonin concentrations were much higher in PR than in vIIIV (19,934 6,388 vs… CONTINUE READING
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