Melatonin Attenuates Her-2, p38 MAPK, p-AKT, and mTOR Levels in Ovarian Carcinoma of Ethanol-Preferring Rats

@inproceedings{Ferreira2014MelatoninAH,
  title={Melatonin Attenuates Her-2, p38 MAPK, p-AKT, and mTOR Levels in Ovarian Carcinoma of Ethanol-Preferring Rats},
  author={Grazielle M. Ferreira and Marcelo Mart{\'i}nez and Isabel Cristina Cherici Camargo and Raquel Fantin Domeniconi and Francisco Eduardo Martinez and Luiz Gustavo de Almeida Chuffa},
  booktitle={Journal of Cancer},
  year={2014}
}
Epidermal growth factor receptors 2 (Her-2) and 4 (Her-4) are closely associated with ovarian cancer (OC) progression and metastasis, and a more complete understanding of these signaling pathways allow the development of new therapeutic strategies. Melatonin (Mel) is recognized as having several anticancer properties and has been reported to modulate Her-2 system in aggressive tumors. Here, we investigated OC and the role of Mel therapy on the Her-2- and Her-4-signaling pathway related to… CONTINUE READING
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