Melatonin--a pleiotropic molecule involved in pathophysiological processes following organ transplantation.

@article{Fildes2009MelatoninaPM,
  title={Melatonin--a pleiotropic molecule involved in pathophysiological processes following organ transplantation.},
  author={James E. Fildes and Nizar N Yonan and Brian G Keevil},
  journal={Immunology},
  year={2009},
  volume={127 4},
  pages={443-9}
}
Mammals adjust their physiology in response to seasonal changes to environment (i.e. photoperiod, temperature, food availability). These changes are thought to predominantly occur for the conservation of energy during winter, by pervasive changes such as the inhibition of reproduction. Previous reports have suggested that circannual changes also occur to the immune system. In mammals, this chronological effect may be dependent on photoperiod, and evidence exists to suggest that there is a great… CONTINUE READING