Melatonin: therapeutic and clinical utilization

  title={Melatonin: therapeutic and clinical utilization},
  author={Armağan Altun and Betul Ugur-Altun},
  journal={International Journal of Clinical Practice},
Melatonin, acting through melatonin receptors, is involved in numerous physiological processes including circadian entrainment, blood pressure regulation, oncogenesis, retinal physiology, seasonal reproduction, ovarian physiology, immune function and most recently in inducing osteoblast differentiation. Moreover, melatonin was proved to be a potent‐free radical scavenger and a broad‐spectrum antioxidant. More research is required into the effects of therapeutically modulating the melatoninergic… 

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Melatonin, the Pineal Gland and their Implications for Headache Disorders

  • M. Peres
  • Medicine, Biology
    Cephalalgia : an international journal of headache
  • 2005
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The immunoneuroendocrine role of melatonin

The pineal gland might be viewed as the crux of a sophisticated immunoneuroendocrine network which functions as an unconscious, diffuse sensory organ that is particularly apparent in immunodepressive states.

Some effects of melatonin and the control of its secretion in humans.

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Is there a role for melatonin in supportive care?

  • P. Lissoni
  • Medicine, Biology
    Supportive Care in Cancer
  • 2002
The present clinical results demonstrate that the pineal hormone MLT may be successfully administered in medical oncology in the supportive care of untreatable advanced cancer patients and for the prevention of chemotherapy-induced toxicity.

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Considering the low toxicity of melatonin and its ability to reduce the side effects and increase the efficacy of these drugs, its use as a combination therapy with these agents seems important and worthy of pursuit.

Melatonin as a chronobiotic.