Melatonin: therapeutic and clinical utilization

  title={Melatonin: therapeutic and clinical utilization},
  author={Armağan Altun and Betul Ugur-Altun},
  journal={International Journal of Clinical Practice},
Melatonin, acting through melatonin receptors, is involved in numerous physiological processes including circadian entrainment, blood pressure regulation, oncogenesis, retinal physiology, seasonal reproduction, ovarian physiology, immune function and most recently in inducing osteoblast differentiation. Moreover, melatonin was proved to be a potent‐free radical scavenger and a broad‐spectrum antioxidant. More research is required into the effects of therapeutically modulating the melatoninergic… 
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Melatonin: from basic research to cancer treatment clinics.
The evidence regarding the potential use of melatonin in cancer treatment is summarized and rationale for the design of larger translational research-based clinical trials is provided.
The immunoneuroendocrine role of melatonin
The pineal gland might be viewed as the crux of a sophisticated immunoneuroendocrine network which functions as an unconscious, diffuse sensory organ that is particularly apparent in immunodepressive states.
Some effects of melatonin and the control of its secretion in humans.
The results suggest that fatigue (or alertness) may be entrained by melatonin, but whether critical performance rhythms can be suitably manipulated remains to be clarified.
Is there a role for melatonin in supportive care?
  • P. Lissoni
  • Medicine, Biology
    Supportive Care in Cancer
  • 2002
The present clinical results demonstrate that the pineal hormone MLT may be successfully administered in medical oncology in the supportive care of untreatable advanced cancer patients and for the prevention of chemotherapy-induced toxicity.
Melatonin: reducing the toxicity and increasing the efficacy of drugs
Considering the low toxicity of melatonin and its ability to reduce the side effects and increase the efficacy of these drugs, its use as a combination therapy with these agents seems important and worthy of pursuit.
Melatonin as a chronobiotic.
Immunomodulatory effects of melatonin in asthma.
Differential immunomodulatory effects of melatonin based on asthma clinical phenotype and may indicate an adverse effect of exogenous melatonin in asthma are suggested.
Impaired nocturnal melatonin secretion in non-dipper hypertensive patients.
NDIP hypertensive patients differ from DIP hypertensives by having an impaired nocturnal melatonin secretion, suggesting that melatonin may play a role in the circadian rhythm of blood pressure in hypertensive Patients.