Melatonin: therapeutic and clinical utilization

@article{Altun2007MelatoninTA,
  title={Melatonin: therapeutic and clinical utilization},
  author={Armağan Altun and Betul Ugur-Altun},
  journal={International Journal of Clinical Practice},
  year={2007},
  volume={61}
}
Melatonin, acting through melatonin receptors, is involved in numerous physiological processes including circadian entrainment, blood pressure regulation, oncogenesis, retinal physiology, seasonal reproduction, ovarian physiology, immune function and most recently in inducing osteoblast differentiation. Moreover, melatonin was proved to be a potent‐free radical scavenger and a broad‐spectrum antioxidant. More research is required into the effects of therapeutically modulating the melatoninergic… 
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219 Citations
Highly Influential Citations
5
Background Citations
88
Methods Citations
1
Results Citations
4

219 Citations

Antiinflammatory Activity of Melatonin in Central Nervous System

The authors examine the effect of melatonin on several neurological diseases with inflammatory components, including dementia, Alzheimer disease, Parkinson disease, multiple sclerosis, stroke, and brain ischemia/reperfusion but also in traumatic CNS injuries.

Melatonin, Sleep, and Allergy

Besides direct effects on sleep, melatonin appears to have both immunomodulatory and anti-inflammatory effects and has potential benefit in treating allergic dermatitis, but clinical trial data are limited.

MELATONIN : A NOVEL BIOMATERIAL FOR IMMUNOTHERAPY

The mainly deliberate endocrine product of the pineal gland, melatonin, has been reported to be involved in the feedback between neuroendocrine and immune functions and to exert oncostatic action, at…

Melatonin and its ubiquitous anticancer effects

The underlying anticancer mechanisms of Melatonin such as stimulation of apoptosis, Melatonin receptors (MT1 and MT2) stimulation, paro-survival signal regulation, the hindering of angiogenesis, epigenetic alteration and metastasis have been discussed with recent findings.

Melatonin as a potential inhibitory agent in head and neck cancer

Evidence discussed in this article will serve as a basis for basic and clinical research to promote the use of melatonin for understanding and controlling the development of head and neck cancers.

The Potential of Melatonin for the Application in Dairy Products

Fermented milk supplemented with melatonin-rich plants and yeasts can be used for the effective treatment of sleep disorders and its functional properties are reviewed.

Melatonin, an ubiquitous metabolic regulator: functions, mechanisms and effects on circadian disruption and degenerative diseases

This overview includes recent and relevant literature data related to the impact of endogenous and exogeneous melatonin on the prevention of cancer progression and treatment of various degenerative diseases.

Benefits and adverse events of melatonin use in the elderly (Review)

There is an inconsistency of scientific data regarding the lowest optimal dose and safety of melatonin for long-term use, and the evidence on the role ofmelatonin in various clinical conditions is summarized to highlight the future research in this area.

Insights on melatonin as an active pharmacological molecule in cancer prevention: what's new?

This article tried to review the most recent evidence regarding the protective as well as the antitumoral mechanisms of melatonin, as related to diet and metabolic balance.

Therapeutic potential of melatonin in traumatic central nervous system injury

This mini review consolidates the data regarding the efficacy of melatonin as an unique neuroprotective agent in traumatic central nervous system (CNS) injuries and outlines research on traumatic brain injury and ischemia/reperfusion.
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157 References

Melatonin: from basic research to cancer treatment clinics.

The evidence regarding the potential use of melatonin in cancer treatment is summarized and rationale for the design of larger translational research-based clinical trials is provided.

Melatonin, the Pineal Gland and their Implications for Headache Disorders

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  • Medicine, Biology
    Cephalalgia : an international journal of headache
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The pineal gland might be viewed as the crux of a sophisticated immunoneuroendocrine network which functions as an unconscious, diffuse sensory organ that is particularly apparent in immunodepressive states.

Some effects of melatonin and the control of its secretion in humans.

The results suggest that fatigue (or alertness) may be entrained by melatonin, but whether critical performance rhythms can be suitably manipulated remains to be clarified.

Is there a role for melatonin in supportive care?

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  • Medicine, Biology
    Supportive Care in Cancer
  • 2002
The present clinical results demonstrate that the pineal hormone MLT may be successfully administered in medical oncology in the supportive care of untreatable advanced cancer patients and for the prevention of chemotherapy-induced toxicity.

Circadian organization of the immune response: A role for melatonin

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This work provides the first biological explanation of melatonin-induced enhancement of the efficacy and reduced toxicity of chemo- and radiotherapy in cancer patients and represents a potentially unifying model for the chronobiological inhibitory regulation of cancer growth by melatonin in the maintenance of the host/cancer balance.

Melatonin: reducing the toxicity and increasing the efficacy of drugs

Considering the low toxicity of melatonin and its ability to reduce the side effects and increase the efficacy of these drugs, its use as a combination therapy with these agents seems important and worthy of pursuit.

Melatonin as a chronobiotic.

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