Melatonin: signaling mechanisms of a pleiotropic agent.

  title={Melatonin: signaling mechanisms of a pleiotropic agent.},
  author={R{\"u}diger Hardeland},
  volume={35 2},
Melatonin acts both as a hormone of the pineal gland and as a local regulator molecule in various tissues. Quantities of total tissue melatonin exceed those released from the pineal. With regard to this dual role, to the orchestrating, systemic action on various target tissues, melatonin is highly pleiotropic. Numerous secondary effects result from the control of the circadian pacemaker and, in seasonal breeders, of the hypothalamic/pituitary hormonal axes. In mammals, various binding sites for… CONTINUE READING
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