Melatonin: functions and ligands.

  title={Melatonin: functions and ligands.},
  author={Mahaveer Singh and Hemant Ramanlal Jadhav},
  journal={Drug discovery today},
  volume={19 9},
Melatonin is a chronobiotic substance that acts as synchronizer by stabilizing bodily rhythms. Its synthesis occurs in various locations throughout the body, including the pineal gland, skin, lymphocytes and gastrointestinal tract (GIT). Its synthesis and secretion is controlled by light and dark conditions, whereby light decreases and darkness increases its production. Thus, melatonin is also known as the 'hormone of darkness'. Melatonin and analogs that bind to the melatonin receptors are… CONTINUE READING