Melatonin: exceeding expectations.

  title={Melatonin: exceeding expectations.},
  author={Russel Joseph Reiter and Dun-Xian Tan and Annia Galano},
  volume={29 5},
Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing… 

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