Melatonin: exceeding expectations.

@article{Reiter2014MelatoninEE,
  title={Melatonin: exceeding expectations.},
  author={Russel Joseph Reiter and Dun-Xian Tan and Annia Galano},
  journal={Physiology},
  year={2014},
  volume={29 5},
  pages={
          325-33
        }
}
Melatonin is a small, highly conserved indole with numerous receptor-mediated and receptor-independent actions. Receptor-dependent functions include circadian rhythm regulation, sleep, and cancer inhibition. The receptor-independent actions relate to melatonin's ability to function in the detoxification of free radicals, thereby protecting critical molecules from the destructive effects of oxidative stress under conditions of ischemia/reperfusion injury (stroke, heart attack), ionizing… 
View on PubMed
physiologyonline.physiology.org
427 Citations
Highly Influential Citations
11
Background Citations
155
Methods Citations
1
Results Citations
1

Figures from this paper

427 Citations

Signalling Pathways Targeted by Melatonin in Cancer. A Short Review

Melatonin shows a sharp peak of secretion at night, delivering the circadian message to the organism, and exerts receptor-independent functions, such as detoxification of free radicals, protecting key molecules from oxidative stress under conditions of ischemia, drug toxicity or ionizing radiation.

The multiple functions of melatonin in regenerative medicine

Melatonin: Antiproliferative Actions and Protection of Normal Tissue andEnhancement of Radiosensitivity of Breast Cancer Cells

Melatonin is a small indolamine produced in mammals by the pineal gland, which regulates the sleep-wake cycle in humans, transducing the changes of environmental lightning into a darkness production…

An Overview of Melatonin as an Antioxidant Molecule: A Biochemical Approach

Melatonin prevents degenerative changes in the central nervous system in models of Alzheimer's and Parkinson’s disease and reduces free radical damage to DNA which may lead to cancer and many other situations.

Empowering Melatonin Therapeutics with Drosophila Models

The multiple functions of melatonin are reviewed through the lens of functional conservation and model organism research to empower potential melatonin therapeutics to treat neurodegenerative and renal diseases.

Physiological and pharmacological perspectives of melatonin

    S. Samanta
    Biology
    Archives of physiology and biochemistry
  • 2020
This review will touch the most of the area of melatonin-oriented health impacts and its therapeutic aspects as it synchronises internal rhythm with daily and seasonal variations, regulates circadian rhythm and sleep-wake cycle.

Melatonin as a potential inhibitory agent in head and neck cancer

Evidence discussed in this article will serve as a basis for basic and clinical research to promote the use of melatonin for understanding and controlling the development of head and neck cancers.

Pathophysiological and pharmacological modulation of melatonergic system

This review highlights the pathophysiological and pharmacological actions of melatonin along with melatonergic agonists in “real life” clinical practice.

Docking studies for melatonin receptors

Understanding the second messenger mechanisms involved in melatonin actions, as well as the characteristics of the docking of this molecule to MT1 and MT2 melatonin receptors, will permit the development of more selective agonists and antagonists which will help to better understand this molecule as well to develop new therapeutic compounds.

Melatonin and Health: Insights of Melatonin Action, Biological Functions, and Associated Disorders

The biochemistry of melatonin is described along with its therapeutic potential in various diseases of humans and it is shown that it could be used as potential analgesic drug in diseases associated with pain and it has quite promising role there.
...

75 References

Melatonin membrane receptors in peripheral tissues: Distribution and functions

Functional MT1 and MT2 melatonin receptors in mammals

The melatonin-mediated responses elicited by activation of MT1 and MT2 native melatonin receptors are dependent on circadian time, duration and mode of exposure to endogenous or exogenous melatonin, and functional receptor sensitivity.

Melatonin: Signaling mechanisms of a pleiotropic agent

Melatonin acts both as a hormone of the pineal gland and as a local regulator molecule in various tissues, and cross‐talks between different signaling pathways, including influences of the membrane receptors on nuclear binding sites, are discussed.

Reactive Oxygen Intermediates, Molecular Damage, and Aging: Relation to Melatonin

Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger and indirect antioxidant and acts to stabilize cell membranes, thereby making them more resistant to oxidative attack.

The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives.

The findings from experimental models of numerous diseases overwhelming confirm that this indoleamine would likely have great benefit in aiding humans suffering with conditions that have as their basis tissue and molecular damage resulting from oxygen and nitrogen-based reactants.

Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

Research in the next decade will help to define the role of melatonin in age-related diseases and in determining successful aging, and improving health and the quality of life in the aged should be an aim of this research.

Regulation of antioxidant enzymes: a significant role for melatonin

This report reviews the studies which document the influence of melatonin on the activity and expression of the antioxidative enzymes glutathione peroxidase, superoxide dismutases and catalase both under physiological and under conditions of elevated oxidative stress and analyses the possible mechanisms by which melatonin regulates these enzymes.

Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms

Melatonin, being a highly pleiotropic regulator molecule, interacts directly or indirectly with all the processes mentioned, and a support of healthy aging has been observed in rodents and is highly likely in humans.

Melatonin: An Established Antioxidant Worthy of Use in Clinical Trials

Melatonin is a multifunctional indolamine that counteracts virtually all pathophysiologic steps and displays significant beneficial actions against peroxynitrite-induced cellular toxicity, related to melatonin’s antioxidative and antiinflammatory properties.

Distribution of melatonin in mammalian tissues: The relative importance of nuclear versus cytosolic localization

The administration of exogenous melatonin resulted in a marked increase in the nuclear melatonin content without a concomitant change in the cytosolic fraction, and its location in the nucleus suggests possible genomic actions.
...