Melatonin: detoxification of oxygen and nitrogen-based toxic reactants.

@article{Reiter2003MelatoninDO,
  title={Melatonin: detoxification of oxygen and nitrogen-based toxic reactants.},
  author={R. Reiter and D. Tan and L. Manchester and S. L{\'o}pez-Burillo and R. Sainz and J. Mayo},
  journal={Advances in experimental medicine and biology},
  year={2003},
  volume={527},
  pages={
          539-48
        }
}
  • R. Reiter, D. Tan, +3 authors J. Mayo
  • Published 2003
  • Chemistry, Medicine
  • Advances in experimental medicine and biology
In the last decade, melatonin has been found to be highly protective against damage to macromolecules resulting from oxygen and nitrogen-based reactants. Considering this, numerous studies have examined the mechanisms whereby this indoleamine directly detoxifies these damaging agents. The evidence is compelling that melatonin scavenges several oxygen-derived reactive agents including the hydroxyl radical (OH), hydrogen peroxide (H2O2), singlet oxygen (1O2) and hypochlorous acid (HOCl… Expand
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