Melatonin: an ancient molecule that makes oxygen metabolically tolerable

@article{Manchester2015MelatoninAA,
  title={Melatonin: an ancient molecule that makes oxygen metabolically tolerable},
  author={L. Manchester and A. Coto-Montes and J. A. Boga and L. P. H. Andersen and Zhou Zhou and A. Galano and J. Vriend and D. Tan and R. Reiter},
  journal={Journal of Pineal Research},
  year={2015},
  volume={59}
}
Melatonin is remarkably functionally diverse with actions as a free radical scavenger and antioxidant, circadian rhythm regulator, anti‐inflammatory and immunoregulating molecule, and as an oncostatic agent. We hypothesize that the initial and primary function of melatonin in photosynthetic cyanobacteria, which appeared on Earth 3.5–3.2 billion years ago, was as an antioxidant. The evolution of melatonin as an antioxidant by this organism was necessary as photosynthesis is associated with the… Expand

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References

SHOWING 1-10 OF 248 REFERENCES
Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes
TLDR
It is the hypothesis that mitochondria and chloroplasts are the original sites of melatonin synthesis in the early stage of endosymbiotic organisms; this synthetic capacity was carried into host eukaryotes by the above‐mentioned bacteria and preserved during evolution. Expand
Melatonin in plants.
TLDR
Because physiologic concentrations of melatonin in the blood are known to correlate with the total antioxidant capacity of the serum, consuming food-stuffs containing melatonin may be helpful in lowering oxidative stress. Expand
The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness
TLDR
The changing biological roles of melatonin seem to have evolved from its primary function as an antioxidant, which may indicate senescence in terms of a bio‐clock in many organisms. Expand
The universal nature, unequal distribution and antioxidant functions of melatonin and its derivatives.
TLDR
The findings from experimental models of numerous diseases overwhelming confirm that this indoleamine would likely have great benefit in aiding humans suffering with conditions that have as their basis tissue and molecular damage resulting from oxygen and nitrogen-based reactants. Expand
One molecule, many derivatives: A never‐ending interaction of melatonin with reactive oxygen and nitrogen species?
TLDR
This review focuses on melatonin metabolism which includes the synthetic rate‐limiting enzymes, synthetic sites, potential regulatory mechanisms, bioavailability in humans, mechanisms of breakdown and functions of its metabolites. Expand
Circadian Rhythms, Oxidative Stress, and Antioxidative Defense Mechanisms
TLDR
A general effect of oxidative stress may consist in declines of easily oxidizable signaling molecules such as melatonin, and this can have consequences on the circadian intraorganismal organization and expression of overt rhythms. Expand
Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions
TLDR
Although the vast majority of studies proved the antioxidant capacity of melatonin and its derivatives, a few studies using cultured cells found that melatonin promoted the generation of ROS at pharmacological concentrations in several tumor and nontumor cells; thus, melatonin functioned as a conditional pro‐oxidant. Expand
Functional Pleiotropy of the Neurohormone Melatonin: Antioxidant Protection and Neuroendocrine Regulation
  • R. Reiter
  • Medicine, Biology
  • Frontiers in Neuroendocrinology
  • 1995
TLDR
The pineal hormone melatonin exhibits remarkable functional versatility and its ability to cross all morphophysiological barriers and to enter every cell, and all subcellular compartments, potentially have important implications for a wide variety of age-related diseases and to aging itself. Expand
Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin
TLDR
Research in the next decade will help to define the role of melatonin in age-related diseases and in determining successful aging, and improving health and the quality of life in the aged should be an aim of this research. Expand
Melatonin as an antioxidant and its semi-lunar rhythm in green macroalga Ulva sp.
TLDR
Experimental data provide, for the first time, experimental data that support both an antioxidant role for melatonin and its semi-lunar rhythm in macroalgae. Expand
...
1
2
3
4
5
...