Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions

@article{Zhang2014MelatoninAW,
  title={Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions},
  author={Hong-Mei Zhang and Yiqiang Zhang},
  journal={Journal of Pineal Research},
  year={2014},
  volume={57}
}
Melatonin (N‐acetyl‐5‐methoxytryptamine), an indoleamine produced in many organs including the pineal gland, was initially characterized as a hormone primarily involved in circadian regulation of physiological and neuroendocrine function. Subsequent studies found that melatonin and its metabolic derivatives possess strong free radical scavenging properties. These metabolites are potent antioxidants against both ROS (reactive oxygen species) and RNS (reactive nitrogen species). The mechanisms by… Expand
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