Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its anti-aging effects.

@article{Pierpaoli1987MelatoninAP,
  title={Melatonin: a principal neuroimmunoregulatory and anti-stress hormone: its anti-aging effects.},
  author={Walter Pierpaoli and Georges J. M. Maestroni},
  journal={Immunology letters},
  year={1987},
  volume={16 3-4},
  pages={355-61}
}
Major environmental variables such as daily and seasonal changes of light and temperature regulate the daily circadian variations of synthesis and release of the pineal neurohormone N-acetyl-5-methoxytryptamine (melatonin). Melatonin has now been shown to be a potent immunoregulatory agent, and to be able to antagonize the immunosuppressive effects of acute anxiety stress in mice, as measured by antibody production, by thymus weight, and by the capacity of stressed- and evening-melatonin… CONTINUE READING

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